Types of NASSA
Noradrenaline and specific serotoninergic antidepressants (NASSAs)
These are used to treat anxiety disorders, some personality disorders, and types of depression.
Some of these compounds were introduced in the mid-1980s and others even more recently. NASSAs block negative feedback effects on norepinephrine and serotonin secretion by the presynaptic cell. This action increases the concentrations of these neurotransmitters in the synaptic cleft. They also block some serotonin receptors on the postsynaptic cell, which enhances serotonin neurotransmission
Possible side effects include:
- dry mouth
- weight gain
- drowsiness and sedation
- blurred vision
More serious adverse reactions include seizures, white blood cell count reduction, fainting, and allergic reactions.
Examples include Mianserin (Tolvon) and Mirtazapine (Remeron, Avanza, Zispin).